Title: Top Pemiscot County Hotels: 2026 Best Hotels in Pemiscot County - Expedia.com

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## Check prices for these dates

Tonight

[Feb 16 - Feb 17](https://www.expedia.com/Hotel-Search?regionId=553248635976432037&startDate=2026-02-16&endDate=2026-02-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 17 - Feb 18](https://www.expedia.com/Hotel-Search?regionId=553248635976432037&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=553248635976432037&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=553248635976432037&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Pemiscot County hotels

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Farmstead Hotel

[](https://www.expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

Caruthersville

8.8/10

Excellent

(486 reviews)

"Clean room, very nice staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mack

$76 nightly

$86 total

Feb 21 - Feb 22

Total with taxes and fees

[](https://www.expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/f46408d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/b82fe02d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/15afcc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Hayti Caruthersville

[](https://www.expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information)

Hayti

9.4/10

Exceptional

(1,002 reviews)

"It was quick and easy Very friendly Lots of perks for staying there"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Judy

$96 nightly

$109 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information)

![Standard Double Room, 2 Queen Beds, Transfer Shower | Desk, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/690c1aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/717e836e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/16ab8462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/884d70e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Century Casino & Hotel Caruthersville

[](https://www.expedia.com/Caruthersville-Hotels-Century-Casino-Hotel-Caruthersville.h111402094.Hotel-Information)

Caruthersville

8.4/10

Very Good

(116 reviews)

"Really nice place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brett

$119 nightly

$136 total

Mar 18 - Mar 19

Total with taxes and fees

[](https://www.expedia.com/Caruthersville-Hotels-Century-Casino-Hotel-Caruthersville.h111402094.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville 

[](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

Portageville

8.0/10

Very Good

(740 reviews)

"Parking was good, staff was great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Corey

$60 nightly

$65 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/42200/42106/c305de6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Double Room, 2 Double Beds, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/42200/42106/4fe028cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42106/60f3ef97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42106/a269b6ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Hayti North

[](https://www.expedia.com/Hayti-Hotels-Quality-Inn-Hayti-North.h42106.Hotel-Information)

Hayti

6.8/10

(472 reviews)

"My room was very comfortable"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Betti

$62 nightly

$71 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Hayti-Hotels-Quality-Inn-Hayti-North.h42106.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/94000000/93930000/93923800/93923711/5cd1e13a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/94000000/93930000/93923800/93923711/aa77dc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/94000000/93930000/93923800/93923711/6cc3bfef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/94000000/93930000/93923800/93923711/a2474ddb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### House on the hill, with an amazing downtown street view!

[](https://www.expedia.com/Caruthersville-Hotels-House-On-The-Hill.h93923711.Hotel-Information)

Caruthersville

[](https://www.expedia.com/Caruthersville-Hotels-House-On-The-Hill.h93923711.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-02&endDate=2026-03-03&regionId=553248635976432037&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

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## Top Pemiscot County Hotel Reviews

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg)

### The Farmstead Hotel

10/10 Excellent

"Friendly staff"

[](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg)

### New Orleans Inn Portageville 

10/10 Excellent

"Clean room, Comfy bed and quiet surroundings made my quick stay comfortable. Reasonable price, close to restaurants, head shop, gas station and grocery. "

[](https://expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Hampton Inn Blytheville](https://images.trvl-media.com/lodging/1000000/50000/41800/41712/05343fb1_y.jpg)

### Hampton Inn Blytheville

10/10 Excellent

"Room was quiet and staff were friendly!"

[](https://expedia.com/Blytheville-Hotels-Hampton-Inn-Blytheville.h41712.Hotel-Information)

![Drury Inn & Suites Hayti Caruthersville](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031_y.jpg)

### Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"Room was clean and comfortable. Bathroom was clean. Addition of drinks/appetizers for a few hours in the evening is nice. The breakfast was also a nice addition. We would definitely stay again. "

[](https://expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information)

![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](https://images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/537131b5_y.jpg)

###  For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent

"This Lodge was a hit once again! When these girls walked in they couldn't stop complementing each room. We had enough room for everyone to have their own bed and three bathrooms to share! Jim called during our drive over letting us know that the roads were clear and he had salted the front porch. He even went out back to make sure the dock was free of ice when I mentioned that that was one of my favorite features. Also a hit was the stretch of road between the lodge and the park and beyond. We saw 10 Eagles, took two hikes, and had a grocery store less than 10 mi away, This has become my go-to place when bringing groups to Reelfoot Lake State Park!"

[](https://expedia.com/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information)

![Holiday Inn Blytheville by IHG](https://images.trvl-media.com/lodging/1000000/10000/3400/3357/77afceed_y.jpg)

### Holiday Inn Blytheville by IHG

10/10 Excellent

"yes"

[](https://expedia.com/Blytheville-Hotels-Holiday-Inn-Blytheville.h3357.Hotel-Information)

![Great location just across the street from Reelfoot Lake close to boat ramps](https://images.trvl-media.com/lodging/90000000/89880000/89872800/89872735/96df576d_y.jpg)

### Great location just across the street from Reelfoot Lake close to boat ramps

10/10 Excellent

"Everything was good"

[](https://expedia.com/Hornbeak-Hotels-Great-Location-Just-Across-The-Street-From-Reelfoot-Lake-Close-To-Boat-Ramps.h89872735.Hotel-Information)

![Econo Lodge](https://images.trvl-media.com/lodging/1000000/50000/40200/40136/1fd839ba_y.jpg)

### Econo Lodge

10/10 Excellent

"Yes"

[](https://expedia.com/Kennett-Hotels-Econo-Lodge.h40136.Hotel-Information)

![Quality Inn Hayti North](https://images.trvl-media.com/lodging/1000000/50000/42200/42106/8c385867_y.jpg)

### Quality Inn Hayti North

10/10 Excellent

"The staff was great, very clean rooms, great tv,nice breakfast selections."

[](https://expedia.com/Hayti-Hotels-Quality-Inn-Hayti-North.h42106.Hotel-Information)

## Explore a world of travel with Expedia

- Explore a world of travel with Expedia

### Top cities in Pemiscot County

- [Caruthersville Hotels ](https://expedia.com/Caruthersville-Hotels.d55080.Travel-Guide-Hotels)
- [Hayti Hotels ](https://expedia.com/Hayti-Hotels.d6058765.Travel-Guide-Hotels)
- [Steele Hotels ](https://expedia.com/Steele-Hotels.d6125714.Travel-Guide-Hotels)
- [Bragg City Hotels ](https://expedia.com/Bragg-City-Hotels.d3000349295.Travel-Guide-Hotels)
- [Holland Hotels ](https://expedia.com/Holland-Hotels.d553248634983116119.Travel-Guide-Hotels)
- [Cooter Hotels ](https://expedia.com/Cooter-Hotels.d553248634983169640.Travel-Guide-Hotels)
- [Wardell Hotels ](https://expedia.com/Wardell-Hotels.d3000349581.Travel-Guide-Hotels)
- [Braggadocio Hotels ](https://expedia.com/Braggadocio-Hotels.d3000349297.Travel-Guide-Hotels)
- [Acorn Corner Hotels ](https://expedia.com/Acorn-Corner-Hotels.d553248635975849096.Travel-Guide-Hotels)
- [Denton Hotels ](https://expedia.com/Denton-Hotels.d553248635975847501.Travel-Guide-Hotels)

### Hotels near popular Attractions

- [Hotels near Century Casino Caruthersville ](https://expedia.com/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels)
- [Hotels near Hayti Park ](https://expedia.com/Hayti-Park-Hotels.0-l6245776-0.Travel-Guide-Filter-Hotels)
- [Hotels near Caruthersville Public Library ](https://expedia.com/Caruthersville-Public-Library-Hotels.0-l553248621560505649-0.Travel-Guide-Filter-Hotels)
- [Hotels near Hayti Pentecostal Holiness Church ](https://expedia.com/Hayti-Pentecostal-Holiness-Church-Hotels.0-l6245797-0.Travel-Guide-Filter-Hotels)
- [Hotels near Black Island Conservation Area ](https://expedia.com/Black-Island-Conservation-Area-Hotels.0-l553248621560505648-0.Travel-Guide-Filter-Hotels)
- [Hotels near Mississippi River ](https://expedia.com/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels)
- [Hotels near Reelfoot Lake ](https://expedia.com/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels)
- [Hotels near Arkansas Aeroplex ](https://expedia.com/Arkansas-Aeroplex-Hotels.0-l6274726-0.Travel-Guide-Filter-Hotels)
- [Hotels near Marston Community Center ](https://expedia.com/Marston-Community-Center-Hotels.0-l553248622945532712-0.Travel-Guide-Filter-Hotels)
- [Hotels near New Madrid Historical Museum ](https://expedia.com/New-Madrid-Historical-Museum-Hotels.0-l553248621532655748-0.Travel-Guide-Filter-Hotels)

### More Accommodation Types in Pemiscot County

- [Vacation Homes in Pemiscot County ](https://expedia.com/Pemiscot-County-Private-Vacation-Homes.d553248635976432037-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Lodges in Pemiscot County ](https://expedia.com/Pemiscot-County-Lodges.d553248635976432037-aaLodges.Travel-Guide-Accommodation)
- [Motels in Pemiscot County ](https://expedia.com/Pemiscot-County-Motels.d553248635976432037-aaMotels.Travel-Guide-Accommodation)
- [Cottages in Pemiscot County ](https://expedia.com/Pemiscot-County-Cottages.d553248635976432037-aaCottages.Travel-Guide-Accommodation)
- [Cabin Rentals in Pemiscot County ](https://expedia.com/Pemiscot-County-Cabins.d553248635976432037-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Pemiscot County ](https://expedia.com/Pemiscot-County-Apartments.d553248635976432037-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Pemiscot County ](https://expedia.com/Pemiscot-County-Condos.d553248635976432037-aaCondos.Travel-Guide-Accommodation)

### Explore more hotels

- [The Farmstead Hotel ](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)
- [Drury Inn & Suites Hayti Caruthersville ](https://expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information)
- [Century Casino & Hotel Caruthersville ](https://expedia.com/Caruthersville-Hotels-Century-Casino-Hotel-Caruthersville.h111402094.Hotel-Information)
- [Quality Inn Hayti North ](https://expedia.com/Hayti-Hotels-Quality-Inn-Hayti-North.h42106.Hotel-Information)
- [Holiday Inn Blytheville by IHG ](https://expedia.com/Blytheville-Hotels-Holiday-Inn-Blytheville.h3357.Hotel-Information)
- [Holiday Inn Express Hotel & Suites Dyersburg by IHG ](https://expedia.com/Dyersburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Dyersburg.h1541081.Hotel-Information)
- [Comfort Inn & Suites Blytheville ](https://expedia.com/Blytheville-Hotels-Comfort-Inn-Suites.h2032178.Hotel-Information)
- [Hampton Inn Blytheville ](https://expedia.com/Blytheville-Hotels-Hampton-Inn-Blytheville.h41712.Hotel-Information)
- [Econo Lodge ](https://expedia.com/Kennett-Hotels-Econo-Lodge.h40136.Hotel-Information)
- [Sleep Inn & Suites Dyersburg I-155 ](https://expedia.com/Dyersburg-Hotels-Sleep-Inn-Suites-Dyersburg-I-155.h2674308.Hotel-Information)

[See a list of all hotels in Pemiscot County](https://expedia.com/All-Pemiscot-County-Hotels.d553248635976432037.Travel-Guide-City-All-Hotels)

### Expedia's Latest Trends

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- [Luxury Hotels in St. Louis County](https://expedia.com/Destinations-In-St-Louis-County-Luxury-Hotel.0-0-d553248635083900521-tLuxuryHotel.Hotel-Filter-Destinations)
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Flights

- [Benton County Flights](https://expedia.com/lp/flights/553248635976431626/flights-from-benton-county)
- [Flights to St Louis City County](https://expedia.com/Destinations-In-St-Louis-City-County.d553248635976432800.Flight-Destinations)
- [Chariton County Flights](https://expedia.com/lp/flights/553248635976429751/flights-from-chariton-county)
- [Saline County Flights](https://expedia.com/lp/flights/553248635976433051/flights-from-saline-county)
- [Madison County Flights](https://expedia.com/lp/flights/553248635976433936/flights-from-madison-county)
- [Flights to Laclede County](https://expedia.com/Destinations-In-Laclede-County.d553248635976434301.Flight-Destinations)

Cars

- [pickup Car Rentals in St. Louis County](https://expedia.com/Pickup-Car-Rentals-In-St-Louis-County.d553248635083900521-tPickup.Car-Rental-Destination-Class)
- [Car rental St. Louis Airport (STL)](https://expedia.com/Car-Rentals-In-Lambert-St-Louis-Intl.d5002323.Car-Rental-Guide)
- [Car rental Kansas City Airport (MCI)](https://expedia.com/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)
- [Car rental Springfield Airport (SGF)](https://expedia.com/Car-Rentals-In-Springfield-Branson-National.d4605779.Car-Rental-Guide)

Packages

- [St. Louis Zoo](https://expedia.com/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction)

General

- [Visit Downtown Kansas City](https://expedia.com/Kansas-City-Downtown-Kansas-City.dx6058828)
- [Visit Downtown Branson](https://expedia.com/Branson-Downtown-Branson.dx6336866)

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